※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-1393	Si018072m.g	K3YUX6	LOC101759102
2		iEKPD-Sei-1396	Si021288m.g	K3Z420	LOC101760093
3		iEKPD-Sei-1357	Si006195m.g	K3XW87	LOC101763660
4		iEKPD-Sei-1388	Si007080m.g	K3XYS2	LOC101772828
5		iEKPD-Sei-1399	Si000271m.g	K3XEF4	LOC101775701
6		iEKPD-Sei-1378	Si020677m.g	K3Z2A9	LOC101778145
7		iEKPD-Sei-1403	Si000225m.g	K3XEA8	LOC101781896
8		iEKPD-Sei-1359	Si010727m.g	K3Y935	SETIT_010727mg
9		iEKPD-Sei-1366	Si026860m.g	K3ZJV5	SETIT_026860mg