※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0588	ENSTGUG00000004124.1	H0Z101
2		iEKPD-Tag-0612	ENSTGUG00000011298.1	H0ZM22
3		iEKPD-Tag-0605	ENSTGUG00000000299.1	H0YPV2	DUSP1
4		iEKPD-Tag-0616	ENSTGUG00000002705.1	H0YWV8	DUSP10
5		iEKPD-Tag-0586	ENSTGUG00000006604.1	H0Z882	DUSP15
6		iEKPD-Tag-0614	ENSTGUG00000012708.1	H0ZR42	DUSP16
7		iEKPD-Tag-0585	ENSTGUG00000002152.1	H0YVA0	DUSP22
8		iEKPD-Tag-0587	ENSTGUG00000005500.1	H0Z502	DUSP28
9		iEKPD-Tag-0611	ENSTGUG00000004821.1	H0Z323	DUSP4
10		iEKPD-Tag-0617	ENSTGUG00000010605.1	H0ZK16	DUSP5
11		iEKPD-Tag-0613	ENSTGUG00000008053.1	H0ZCI9	DUSP6
12		iEKPD-Tag-0615	ENSTGUG00000006028.1	H0Z6J8	DUSP7
13		iEKPD-Tag-0622	ENSTGUG00000009455.1	H0ZGN3	DUSP8
14		iEKPD-Tag-0610	ENSTGUG00000013102.1	H0ZS96	STYX
15		iEKPD-Tag-0619	ENSTGUG00000004616.1	H0Z2G4	STYXL1