※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265

  Reviewed (0)  or Unreviewed (26) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-4829	TRIAE_CS42_1AS_TGACv1_019770_AA0071270	A0A1D6RDM2
2		iEKPD-Tra-4844	TRIAE_CS42_1BL_TGACv1_033197_AA0137740	A0A1D5SGQ2
3		iEKPD-Tra-4849	TRIAE_CS42_1BS_TGACv1_049587_AA0157320	A0A1D5SJP6
4		iEKPD-Tra-4854	TRIAE_CS42_1DL_TGACv1_061092_AA0184750	A0A1D5SPS2
5		iEKPD-Tra-4871	TRIAE_CS42_1DS_TGACv1_080133_AA0240930	A0A1D5T1C1
6		iEKPD-Tra-4932	TRIAE_CS42_3AL_TGACv1_194119_AA0626810	W5CDA6
7		iEKPD-Tra-4947	TRIAE_CS42_3AS_TGACv1_211010_AA0682990	A0A1D5VHX4
8		iEKPD-Tra-4955	TRIAE_CS42_3B_TGACv1_220908_AA0723420	A0A1D5VQR0
9		iEKPD-Tra-4996	TRIAE_CS42_3DL_TGACv1_251522_AA0882240	W5D8P4
10		iEKPD-Tra-5004	TRIAE_CS42_3DS_TGACv1_272495_AA0921510	A0A1D5WUE7
11		iEKPD-Tra-5066	TRIAE_CS42_5AL_TGACv1_375070_AA1215320	A0A1D5YHE4
12		iEKPD-Tra-5089	TRIAE_CS42_5BL_TGACv1_406088_AA1340570	A0A1D6S3I0
13		iEKPD-Tra-5090	TRIAE_CS42_5BL_TGACv1_406268_AA1343320	A0A1D5Z8N0
14		iEKPD-Tra-5110	TRIAE_CS42_5DL_TGACv1_433774_AA1421720	A0A1D5ZP82
15		iEKPD-Tra-5111	TRIAE_CS42_5DL_TGACv1_433997_AA1426960	W5FV51
16		iEKPD-Tra-5129	TRIAE_CS42_6AL_TGACv1_472187_AA1518870	A0A1D6A9F9
17		iEKPD-Tra-5170	TRIAE_CS42_6DL_TGACv1_528006_AA1710700	W5GUB0
18		iEKPD-Tra-5186	TRIAE_CS42_7AL_TGACv1_558104_AA1790220	W5H8N8
19		iEKPD-Tra-5187	TRIAE_CS42_7AL_TGACv1_559061_AA1797850	A0A1D6BR42
20		iEKPD-Tra-5199	TRIAE_CS42_7AS_TGACv1_571813_AA1850070	A0A1D6C168
21		iEKPD-Tra-5200	TRIAE_CS42_7BL_TGACv1_576748_AA1853500	A0A1D6C1N4
22		iEKPD-Tra-5213	TRIAE_CS42_7BS_TGACv1_593169_AA1948980	A0A1D6CII0
23		iEKPD-Tra-5214	TRIAE_CS42_7BS_TGACv1_593169_AA1949010	A0A1D6CII1
24		iEKPD-Tra-5215	TRIAE_CS42_7DL_TGACv1_602539_AA1959890	W5I1G8
25		iEKPD-Tra-5234	TRIAE_CS42_7DS_TGACv1_632946_AA2067930	A0A1D6D690
26		iEKPD-Tra-4960	TRIAE_CS42_3B_TGACv1_221472_AA0741700	W5CU29	TRAES_3BF099600040CFD_c1