Vicugna pacos      DSP/MKP


※ MKP family introduction

    MAPK phosphatase (MKP) is a large family of dual-specificity phosphatases. The family members are characterized by the C-terminal catalytic domains which share the sequence similarity with prototypic dual-specificity protein phosphatase VH-1 and the N-terminal domain contains two regions of sequence similarity to the catalytic domain of the Cdc25 phosphatase. MKP is involved in varieties of cellular processes. DUSP10/MKP-5 can negatively regulate the JNK signaling pathway and plays an important role in negatively regulating innate immune responses and proper T cell function. In addition, DUSP10/MKP-5 can regulate p38 MAPK activity. DUSP1/MKP-1 is involved in regulating metabolic by dephosphorylating its MAPK substrates. DUSP9/MKP-4 plays a critical role in placental development and function. DUSP6/MKP-3 acts as a negative feedback regulator of fibroblast growth factor signaling (1).

Reference
1. Dickinson, R.J. and Keyse, S.M. (2006) Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci, 119, 4607-4615. PMID: 17093265


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Vip-0321
ENSVPAG00000001440.1
2
iEKPD-Vip-0328
ENSVPAG00000001742.1
3
iEKPD-Vip-0333
ENSVPAG00000001978.1
4
iEKPD-Vip-0348
ENSVPAG00000004137.1
5
iEKPD-Vip-0355
ENSVPAG00000004643.1
6
iEKPD-Vip-0360
ENSVPAG00000005237.1
7
iEKPD-Vip-0373
ENSVPAG00000006702.1
8
iEKPD-Vip-0412
ENSVPAG00000011893.1
9
iEKPD-Vip-0416
ENSVPAG00000011987.1
10
iEKPD-Vip-0418
ENSVPAG00000012229.1