※ PTEN family introduction

    PTEN (phosphatase and tensin homolog deleted on chromosome ten) phosphatase is a conserved family of DUSP phosphatase, which could dephosphorylate tyrosine-, serine- and threonine-phosphorylated proteins. PTEN also acts as lipid phosphatase, which dephosphorylates D3-phosphorylated inositol phospholopids (1). PTEN negatively regulates PI3 kinase-Akt signaling pathway by converting second messenger phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2). This pathway plays an important role in controlling cell proliferation, growth and survival (2). In addition to its dominant inhibitory activity in the PI3 kinase-Akt pathway, PTEN also possess potential protein phosphatase activity for its sequence similarity with PTP domain and this remains more understood.

Reference
1. Patterson, K.I., Brummer, T., O'Brien, P.M. and Daly, R.J. (2009) Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J, 418, 475-489. PMID: 19228121
2. Wang, X. and Jiang, X. (2008) PTEN: a default gate-keeping tumor suppressor with a versatile tail. Cell Res, 18, 807-816. PMID: 18626510

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-g036	SELMODRAFT_119308	D8SKU3	SELMODRAFT_119308
2		iEKPD-Sem-1420	SELMODRAFT_132165	D8T531	SELMODRAFT_132165
3		iEKPD-Sem-1430	SELMODRAFT_165134	D8QSS2	SELMODRAFT_165134
4		iEKPD-Sem-g038	SELMODRAFT_167047	D8R1F5	SELMODRAFT_167047
5		iEKPD-Sem-1427	SELMODRAFT_167184	D8R200	SELMODRAFT_167184
6		iEKPD-Sem-g013	SELMODRAFT_74599	D8QPN4	SELMODRAFT_74599
7		iEKPD-Sem-g001	SELMODRAFT_77222	D8QS90	SELMODRAFT_77222
8		iEKPD-Sem-1424	SELMODRAFT_91219	D8RCM2	SELMODRAFT_91219