※ PTEN family introduction

    PTEN (phosphatase and tensin homolog deleted on chromosome ten) phosphatase is a conserved family of DUSP phosphatase, which could dephosphorylate tyrosine-, serine- and threonine-phosphorylated proteins. PTEN also acts as lipid phosphatase, which dephosphorylates D3-phosphorylated inositol phospholopids (1). PTEN negatively regulates PI3 kinase-Akt signaling pathway by converting second messenger phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2). This pathway plays an important role in controlling cell proliferation, growth and survival (2). In addition to its dominant inhibitory activity in the PI3 kinase-Akt pathway, PTEN also possess potential protein phosphatase activity for its sequence similarity with PTP domain and this remains more understood.

Reference
1. Patterson, K.I., Brummer, T., O'Brien, P.M. and Daly, R.J. (2009) Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J, 418, 475-489. PMID: 19228121
2. Wang, X. and Jiang, X. (2008) PTEN: a default gate-keeping tumor suppressor with a versatile tail. Cell Res, 18, 807-816. PMID: 18626510

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-1511	Si029178m.g	K3ZRE8	LOC101758319
2		iEKPD-Sei-g019	Si000186m.g	K3XE69	LOC101760586
3		iEKPD-Sei-g016	Si015683m.g	K3YN47	LOC101781254
4		iEKPD-Sei-g012	Si006300m.g	K3XWJ2	LOC101781471
5		iEKPD-Sei-g028	Si002712m.g	K3XLD9	SETIT_002712mg
6		iEKPD-Sei-g023	Si016292m.g	K3YPV0	SETIT_016292mg
7		iEKPD-Sei-g018	Si020946m.g	K3Z328	SETIT_020946mg
8		iEKPD-Sei-g020	Si028729m.g	K3ZQ49	SETIT_028729mg