※ PTEN family introduction

    PTEN (phosphatase and tensin homolog deleted on chromosome ten) phosphatase is a conserved family of DUSP phosphatase, which could dephosphorylate tyrosine-, serine- and threonine-phosphorylated proteins. PTEN also acts as lipid phosphatase, which dephosphorylates D3-phosphorylated inositol phospholopids (1). PTEN negatively regulates PI3 kinase-Akt signaling pathway by converting second messenger phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2). This pathway plays an important role in controlling cell proliferation, growth and survival (2). In addition to its dominant inhibitory activity in the PI3 kinase-Akt pathway, PTEN also possess potential protein phosphatase activity for its sequence similarity with PTP domain and this remains more understood.

Reference
1. Patterson, K.I., Brummer, T., O'Brien, P.M. and Daly, R.J. (2009) Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J, 418, 475-489. PMID: 19228121
2. Wang, X. and Jiang, X. (2008) PTEN: a default gate-keeping tumor suppressor with a versatile tail. Cell Res, 18, 807-816. PMID: 18626510

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0687	ENSTGUG00000012019.1	H0ZP57
2		iEKPD-Tag-0678	ENSTGUG00000014908.1	H0ZXB4
3		iEKPD-Tag-0692	ENSTGUG00000010011.1	H0ZIB5	DNAJC6
4		iEKPD-Tag-0676	ENSTGUG00000018302.1	H1A5T3	LOC105759670
5		iEKPD-Tag-0690	ENSTGUG00000004977.1	H0Z3J8	PTEN
6		iEKPD-Tag-1315	ENSTGUG00000005126.1	H0Z413	TNS1
7		iEKPD-Tag-1314	ENSTGUG00000007104.1	H0Z9T5	TNS3