※ SSH family introduction

    Slingshot is a family of DUSP protein phosphatase and contains three members in human genome, which are known as SSH1, SSH2 and SSH3. SSH phosphatase mainly functions as regulators of actin filament dynamics through dephosphorylating cofilin. Dephosphorylation of cofilin stimulates its activity and then cofilin binds to F-Actin, stimulates F-actin depolymerization and severing (1). In addition, SSH phosphatase and LIMK play an important role in directing cell migration (2).

Reference
1. Huang, T.Y., DerMardirossian, C. and Bokoch, G.M. (2006) Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol, 18, 26-31. PMID: 16337782
2. Nishita, M., Tomizawa, C., Yamamoto, M., Horita, Y., Ohashi, K. and Mizuno, K. (2005) Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol, 171, 349-359. PMID: 16230460

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dar-1160	ENSDARG00000079591.4	E7EZK3	si:ch211-203d1.3
2		iEKPD-Dar-1164	ENSDARG00000056780.6	X1WHN2	ssh1a
3		iEKPD-Dar-1163	ENSDARG00000010031.8	E9QGK0	ssh1b
4		iEKPD-Dar-1166	ENSDARG00000088440.3	E7FH10	ssh2a
5		iEKPD-Dar-1165	ENSDARG00000098955.1	A0A0R4IAC0	ssh2b