※ SSH family introduction

    Slingshot is a family of DUSP protein phosphatase and contains three members in human genome, which are known as SSH1, SSH2 and SSH3. SSH phosphatase mainly functions as regulators of actin filament dynamics through dephosphorylating cofilin. Dephosphorylation of cofilin stimulates its activity and then cofilin binds to F-Actin, stimulates F-actin depolymerization and severing (1). In addition, SSH phosphatase and LIMK play an important role in directing cell migration (2).

Reference
1. Huang, T.Y., DerMardirossian, C. and Bokoch, G.M. (2006) Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol, 18, 26-31. PMID: 16337782
2. Nishita, M., Tomizawa, C., Yamamoto, M., Horita, Y., Ohashi, K. and Mizuno, K. (2005) Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol, 171, 349-359. PMID: 16230460

  Reviewed (3)  or Unreviewed (0) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mum-0616	ENSMUSG00000042121.16	Q76I79	Ssh1
2		iEKPD-Mum-0619	ENSMUSG00000037926.15	Q5SW75	Ssh2
3		iEKPD-Mum-0611	ENSMUSG00000034616.16	Q8K330	Ssh3