※ SSH family introduction

    Slingshot is a family of DUSP protein phosphatase and contains three members in human genome, which are known as SSH1, SSH2 and SSH3. SSH phosphatase mainly functions as regulators of actin filament dynamics through dephosphorylating cofilin. Dephosphorylation of cofilin stimulates its activity and then cofilin binds to F-Actin, stimulates F-actin depolymerization and severing (1). In addition, SSH phosphatase and LIMK play an important role in directing cell migration (2).

Reference
1. Huang, T.Y., DerMardirossian, C. and Bokoch, G.M. (2006) Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol, 18, 26-31. PMID: 16337782
2. Nishita, M., Tomizawa, C., Yamamoto, M., Horita, Y., Ohashi, K. and Mizuno, K. (2005) Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol, 171, 349-359. PMID: 16230460

  Reviewed (0)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Orn-0792	ENSONIG00000007974.1	I3JME9
2		iEKPD-Orn-0794	ENSONIG00000013423.1	I3K6Y2	ssh1
3		iEKPD-Orn-0793	ENSONIG00000013932.1	I3K8R8	SSH1 (1 of many)
4		iEKPD-Orn-0787	ENSONIG00000005567.1	I3JDR0	SSH2 (1 of many)