※ SSH family introduction

    Slingshot is a family of DUSP protein phosphatase and contains three members in human genome, which are known as SSH1, SSH2 and SSH3. SSH phosphatase mainly functions as regulators of actin filament dynamics through dephosphorylating cofilin. Dephosphorylation of cofilin stimulates its activity and then cofilin binds to F-Actin, stimulates F-actin depolymerization and severing (1). In addition, SSH phosphatase and LIMK play an important role in directing cell migration (2).

Reference
1. Huang, T.Y., DerMardirossian, C. and Bokoch, G.M. (2006) Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol, 18, 26-31. PMID: 16337782
2. Nishita, M., Tomizawa, C., Yamamoto, M., Horita, Y., Ohashi, K. and Mizuno, K. (2005) Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol, 171, 349-359. PMID: 16230460

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Otg-0627	ENSOGAG00000014046.2	H0XAD9	SSH1
2		iEKPD-Otg-0632	ENSOGAG00000000807.2	H0WH88	SSH2
3		iEKPD-Otg-0620	ENSOGAG00000010647.2	H0X354	SSH3