※ SSH family introduction

    Slingshot is a family of DUSP protein phosphatase and contains three members in human genome, which are known as SSH1, SSH2 and SSH3. SSH phosphatase mainly functions as regulators of actin filament dynamics through dephosphorylating cofilin. Dephosphorylation of cofilin stimulates its activity and then cofilin binds to F-Actin, stimulates F-actin depolymerization and severing (1). In addition, SSH phosphatase and LIMK play an important role in directing cell migration (2).

Reference
1. Huang, T.Y., DerMardirossian, C. and Bokoch, G.M. (2006) Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol, 18, 26-31. PMID: 16337782
2. Nishita, M., Tomizawa, C., Yamamoto, M., Horita, Y., Ohashi, K. and Mizuno, K. (2005) Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol, 171, 349-359. PMID: 16230460

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pof-0660	ENSPFOG00000002117.2	A0A087X8B7
2		iEKPD-Pof-0726	ENSPFOG00000009443.2	A0A096LXT7
3		iEKPD-Pof-0750	ENSPFOG00000010772.2	A0A087XZ17
4		iEKPD-Pof-0835	ENSPFOG00000019778.1	A0A087YPF1	SSH1 (1 of many)
5		iEKPD-Pof-0759	ENSPFOG00000011564.2	A0A087Y0I8	SSH2 (1 of many)