Ailuropoda melanoleuca His-Based PTP/TULA
※ TULA family introduction TULA/STS contains two members, UBASH3A/TULA-1 and UBASH3B/TULA-2. Sequence analysis shows that they share a conserved multidomain structure which contains an N-terminal ubiquitin-association domain, followed by a Src-homology 3 domain, and a C-terminal phosphatase domain. TULA/STS shows tyrosine phosphatase activity toward para-nitrophenyl phosphate, phosphotyrosine peptides and phosphoprotein ZAP70, Syk and certain Src family members. TULA/STS is distinct from other PTP which uses a cysteine residue as a catalytic residue (1). TULA/STS also belongs to the histidine phosphatase superfamily, that shares a conserved catalytic core centred on a histidine which is phosphorylated during the course of the reaction (2). Reference
1. Chen, X., Ren, L., Kim, S., Carpino, N., Daniel, J.L., Kunapuli, S.P., Tsygankov, A.Y. and Pei, D. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem, 285, 31268-31276. PMID: 20670933
2. Rigden DJ. (2008) The histidine phosphatase superfamily: structure and function. Biochem J, 409(2), 333-48. PMID: 18092946
There are 3 genes. Reviewed (0)
or Unreviewed (3) 
※ TULA family introduction TULA/STS contains two members, UBASH3A/TULA-1 and UBASH3B/TULA-2. Sequence analysis shows that they share a conserved multidomain structure which contains an N-terminal ubiquitin-association domain, followed by a Src-homology 3 domain, and a C-terminal phosphatase domain. TULA/STS shows tyrosine phosphatase activity toward para-nitrophenyl phosphate, phosphotyrosine peptides and phosphoprotein ZAP70, Syk and certain Src family members. TULA/STS is distinct from other PTP which uses a cysteine residue as a catalytic residue (1). TULA/STS also belongs to the histidine phosphatase superfamily, that shares a conserved catalytic core centred on a histidine which is phosphorylated during the course of the reaction (2). Reference
1. Chen, X., Ren, L., Kim, S., Carpino, N., Daniel, J.L., Kunapuli, S.P., Tsygankov, A.Y. and Pei, D. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem, 285, 31268-31276. PMID: 20670933
2. Rigden DJ. (2008) The histidine phosphatase superfamily: structure and function. Biochem J, 409(2), 333-48. PMID: 18092946
There are 3 genes. Reviewed (0)
or Unreviewed (3) | No. | Status | iEKPD ID | Ensemble Gene ID | UniProt Accession | Gene Name |
|---|---|---|---|---|---|
| 1 | | ||||
| 2 | | ||||
| 3 | |