※ TULA family introduction

    TULA/STS contains two members, UBASH3A/TULA-1 and UBASH3B/TULA-2. Sequence analysis shows that they share a conserved multidomain structure which contains an N-terminal ubiquitin-association domain, followed by a Src-homology 3 domain, and a C-terminal phosphatase domain. TULA/STS shows tyrosine phosphatase activity toward para-nitrophenyl phosphate, phosphotyrosine peptides and phosphoprotein ZAP70, Syk and certain Src family members. TULA/STS is distinct from other PTP which uses a cysteine residue as a catalytic residue (1). TULA/STS also belongs to the histidine phosphatase superfamily, that shares a conserved catalytic core centred on a histidine which is phosphorylated during the course of the reaction (2).

Reference
1. Chen, X., Ren, L., Kim, S., Carpino, N., Daniel, J.L., Kunapuli, S.P., Tsygankov, A.Y. and Pei, D. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem, 285, 31268-31276. PMID: 20670933
2. Rigden DJ. (2008) The histidine phosphatase superfamily: structure and function. Biochem J, 409(2), 333-48. PMID: 18092946

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0577	ENSTGUG00000015008.1	H0ZXM0	LOC100224390
2		iEKPD-Tag-g021	ENSTGUG00000012270.1	H0ZPV4	TIGAR
3		iEKPD-Tag-0570	ENSTGUG00000005618.1	H0Z5F3	UBASH3A
4		iEKPD-Tag-0565	ENSTGUG00000000479.1	H0YQD1	UBASH3B