※ Haspin family introduction

    Haspin (haploid cell-specific protein kinase) family contains one member in human genome. Haspin was first found in male germ cells of mice and Haspin homologues have been identified in a range of eukaryotic organisms. These homologues contain a divergent kinase catalytic domain which is different with classical ePKs. Experiment shows that expression of Haspin is high in testis in human with low levels in multiple somatic tissues. Haspin is a nuclear protein in interphase nuclei and in round spermatids and is associated with chromosomes in mitosis. Studies show that Haspin depletion can cause a defect in chromosome congression and a delay in exit from mitosis. In addition, Haspin-depleted cells can lead to the chromosome alignment defects and overexpression can prevent the normal dissociation of cohesin from chromosome arms (1).

Reference
1. Higgins, J.M. (2010) Haspin: a newly discovered regulator of mitotic chromosome behavior. Chromosoma, 119, 137-147. PMID: 19997740

  Reviewed (1)  or Unreviewed (13) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cae-0385	WBGene00022670	Q09371	ZK177.2
2		iEKPD-Cae-0165	WBGene00007309	C1P643	C04G2.10
3		iEKPD-Cae-0271	WBGene00015534	Q17723	C06E4.5
4		iEKPD-Cae-0281	WBGene00016137	Q18226	C26E6.1
5		iEKPD-Cae-0177	WBGene00008243	Q18765	C50H2.7
6		iEKPD-Cae-0391	WBGene00044501	Q4PIU0	C55C3.8
7		iEKPD-Cae-0395	WBGene00235269	U4PC52	CELE_F59E12.15
8		iEKPD-Cae-0331	WBGene00019190	Q9N5M9	CELE_H12I13.1
9		iEKPD-Cae-0223	WBGene00012159	Q8T3H2	CELE_VY10G11R.1
10		iEKPD-Cae-g038	WBGene00021302	Q9BPM8	CELE_Y32G9A.3
11		iEKPD-Cae-0240	WBGene00012981	Q9U2A2	CELE_Y48B6A.10
12		iEKPD-Cae-0377	WBGene00022228	Q9N4E6	CELE_Y73B6A.1
13		iEKPD-Cae-0161	WBGene00007258	G5EE25	hasp-1
14		iEKPD-Cae-0367	WBGene00021214	Q9BL96	hasp-2