※ IRE family introduction

    IRE family kinases are endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, family member RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. RNASEL might also play a central role in the regulation of mRNA. turnover (1).

Reference
1. UniProt Annotation: RN5A_HUMAN

  Reviewed (0)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Glm-0060	GLYMA_01G157800	K7K434	100785363
2		iEKPD-Glm-1885	GLYMA_16G111800	K7MGM6	100785904
3		iEKPD-Glm-1030	GLYMA_09G197000	K7LEW9	100788389
4		iEKPD-Glm-1226	GLYMA_11G087200	I1LIC4	102661527