※ PEK family introduction

    PEK family is composed of four kinase members, which are eukaryotic translation initiation factor 2-alpha kinase. Family member EIF2AK1 can inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. EIF2AK1 can exert its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling (1). EIF2AK2 can becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1 following activation by double-stranded RNA in the presence of ATP (2). EIF2AK3 can phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (3).

Reference
1. UniProt Annotation:   E2AK1_HUMAN;
2. UniProt Annotation:   E2AK2_HUMAN;
3. UniProt Annotation:   E2AK3_HUMAN;

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nia-0021	A4A49_01454	A0A1J6I6B4	GCN2_0
2		iEKPD-Nia-0636	A4A49_52637	A0A1J6I670	GCN2_1
3		iEKPD-Nia-0355	A4A49_25772	A0A1J6L1J1	GCN2_3
4		iEKPD-Nia-0401	A4A49_27938	A0A1J6IDG2	GCN2_4
5		iEKPD-Nia-0020	A4A49_01453	A0A1J6IMA0	GCN2_5
6		iEKPD-Nia-0402	A4A49_27940	A0A1J6ITU3	GCN2_6