Triticum aestivum      Other/PEK


※ PEK family introduction

    PEK family is composed of four kinase members, which are eukaryotic translation initiation factor 2-alpha kinase. Family member EIF2AK1 can inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. EIF2AK1 can exert its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling (1). EIF2AK2 can becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1 following activation by double-stranded RNA in the presence of ATP (2). EIF2AK3 can phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (3).

Reference
1. UniProt Annotation:   E2AK1_HUMAN;
2. UniProt Annotation:   E2AK2_HUMAN;
3. UniProt Annotation:   E2AK3_HUMAN;


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Tra-0647
TRIAE_CS42_2AL_TGACv1_094876_AA0304340
A0A1D5TD85
2
iEKPD-Tra-1295
TRIAE_CS42_2DL_TGACv1_161701_AA0560150
A0A1D5UTK4
3
iEKPD-Tra-1908
TRIAE_CS42_3B_TGACv1_225308_AA0806950
A0A1D5W7M2
4
iEKPD-Tra-4236
TRIAE_CS42_7BL_TGACv1_577939_AA1886420
A0A1D6C7C1
5
iEKPD-Tra-0882
TRIAE_CS42_2BL_TGACv1_129909_AA0399260
F4NAR5
TaGCN2