※ SCY family introduction

    SCY1 family is composed of three members in human genome (1). SCYL1 is involved in regulating COPI-mediated retrograde traffic. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region (2). SCYL2 is component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles and may regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (3).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. UniProt Annotation:   NTKL_HUMAN;
3. UniProt Annotation:   SCYL2_HUMAN;

  Reviewed (3)  or Unreviewed (3) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-1539	AT4G11110	Q9T014	SPA2
2		iEKPD-Art-1536	AT3G15354	Q9LJR3	SPA3
3		iEKPD-Art-1532	AT1G53090	Q94BM7	SPA4
4		iEKPD-Art-0089	AT1G22870	F4I313	At1g22870
5		iEKPD-Art-0411	AT2G40730	F4II29	CTEXP
6		iEKPD-Art-0248	AT1G71410	Q9C9H8	F26A9.21