※ SCY family introduction

    SCY1 family is composed of three members in human genome (1). SCYL1 is involved in regulating COPI-mediated retrograde traffic. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region (2). SCYL2 is component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles and may regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (3).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. UniProt Annotation:   NTKL_HUMAN;
3. UniProt Annotation:   SCYL2_HUMAN;

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gor-0394	B456_004G267700	A0A0D2S6R7	B456_004G267700
2		iEKPD-Gor-2349	B456_007G322900	A0A0D2SUG9	B456_007G322900
3		iEKPD-Gor-2351	B456_008G252600	A0A0D2Q1L6	B456_008G252600
4		iEKPD-Gor-1080	B456_009G262900	A0A0D2S8M9	B456_009G262900
5		iEKPD-Gor-1094	B456_009G290500	A0A0D2TX12	B456_009G290500
6		iEKPD-Gor-1096	B456_009G292700	A0A0D2TTU7	B456_009G292700
7		iEKPD-Gor-1132	B456_009G3649001	A0A0D2SEG0	B456_009G3649001
8		iEKPD-Gor-1279	B456_010G219100	A0A0D2SX35	B456_010G219100