※ SCY family introduction

    SCY1 family is composed of three members in human genome (1). SCYL1 is involved in regulating COPI-mediated retrograde traffic. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region (2). SCYL2 is component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles and may regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (3).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. UniProt Annotation:   NTKL_HUMAN;
3. UniProt Annotation:   SCYL2_HUMAN;

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Hea-0119	HannXRQ_Chr01g0028561	A0A251VT75	HannXRQ_Chr01g0028561
2		iEKPD-Hea-0854	HannXRQ_Chr07g0205711	A0A251UFM1	HannXRQ_Chr07g0205711
3		iEKPD-Hea-1213	HannXRQ_Chr10g0298581	A0A251TLG3	HannXRQ_Chr10g0298581
4		iEKPD-Hea-3266	HannXRQ_Chr10g0302771	A0A251TL43	HannXRQ_Chr10g0302771
5		iEKPD-Hea-g036	HannXRQ_Chr11g0330751	A0A251T9M0	HannXRQ_Chr11g0330751
6		iEKPD-Hea-2085	HannXRQ_Chr14g0460671	A0A251SMN6	HannXRQ_Chr14g0460671
7		iEKPD-Hea-2246	HannXRQ_Chr15g0493711	A0A251SCM6	HannXRQ_Chr15g0493711
8		iEKPD-Hea-3113	HannXRQ_Chr10g0292671	A0A251TID1	SPA2