Macaca mulatta      Other/SCY


※ SCY family introduction

    SCY1 family is composed of three members in human genome (1). SCYL1 is involved in regulating COPI-mediated retrograde traffic. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region (2). SCYL2 is component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles and may regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (3).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. UniProt Annotation:   NTKL_HUMAN;
3. UniProt Annotation:   SCYL2_HUMAN;


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Mam-0448
ENSMMUG00000039733.1
A0A1D5QLW5
2
iEKPD-Mam-0419
ENSMMUG00000023477.3
F7E7N6
SCYL1
3
iEKPD-Mam-0423
ENSMMUG00000023600.3
F7HDI2
SCYL2
4
iEKPD-Mam-0278
ENSMMUG00000016583.3
F6VPH8
SCYL3