※ SCY family introduction

    SCY1 family is composed of three members in human genome (1). SCYL1 is involved in regulating COPI-mediated retrograde traffic. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region (2). SCYL2 is component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles and may regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (3).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. UniProt Annotation:   NTKL_HUMAN;
3. UniProt Annotation:   SCYL2_HUMAN;

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-2081	MANES_01G047900	A0A251LML0	MANES_01G047900
2		iEKPD-Mae-0196	MANES_02G207300	A0A2C9WH90	MANES_02G207300
3		iEKPD-Mae-0641	MANES_07G142600	A0A2C9VLG4	MANES_07G142600
4		iEKPD-Mae-0789	MANES_10G002000	A0A2C9V242	MANES_10G002000
5		iEKPD-Mae-2092	MANES_15G087200	A0A251J487	MANES_15G087200
6		iEKPD-Mae-g013	MANES_18G100600	A0A2C9U341	MANES_18G100600