※ SCY family introduction

    SCY1 family is composed of three members in human genome (1). SCYL1 is involved in regulating COPI-mediated retrograde traffic. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region (2). SCYL2 is component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles and may regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (3).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. UniProt Annotation:   NTKL_HUMAN;
3. UniProt Annotation:   SCYL2_HUMAN;

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sol-0204	Solyc02g080020.1	K4B9M3
2		iEKPD-Sol-1695	Solyc07g063120.2	K4CGZ5
3		iEKPD-Sol-0964	Solyc10g054310.1	K4D129
4		iEKPD-Sol-0965	Solyc10g055310.1	K4D1C3
5		iEKPD-Sol-1700	Solyc12g013840.1	K4DCR9
6		iEKPD-Sol-g027	Solyc09g074810.2	K4CV58
7		iEKPD-Sol-g004	Solyc10g055280.1	K4D1C0
8		iEKPD-Sol-0603	Solyc06g048890.2	K4C5D5	101252783
9		iEKPD-Sol-1563	Solyc08g081990.2	K4CPJ5	101263834
10		iEKPD-Sol-0561	Solyc05g052200.2	K4C1Q1	101266824
11		iEKPD-Sol-1039	Solyc11g042990.1	K4D866	101268059