※ SCY family introduction

    SCY1 family is composed of three members in human genome (1). SCYL1 is involved in regulating COPI-mediated retrograde traffic. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region (2). SCYL2 is component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles and may regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (3).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. UniProt Annotation:   NTKL_HUMAN;
3. UniProt Annotation:   SCYL2_HUMAN;

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sob-1742	SORBI_3003G029500	C5XLU4	SORBI_3003G029500
2		iEKPD-Sob-0472	SORBI_3003G220200	C5XR14	SORBI_3003G220200
3		iEKPD-Sob-1745	SORBI_3003G282000	A0A1W0VZA3	SORBI_3003G282000
4		iEKPD-Sob-0531	SORBI_3003G337300	C5XN97	SORBI_3003G337300
5		iEKPD-Sob-0795	SORBI_3005G220740	A0A1Z5RKD2	SORBI_3005G220740
6		iEKPD-Sob-0875	SORBI_3006G229901	A0A1Z5RF80	SORBI_3006G229901