※ TTK family introduction

    TTK is a mammalian homolog of conserved Mps1 family members expressed in all proliferating cells and tissues. TTK was original identified by screening of a T cell expression library with anti-phosphotyrosine antibodies. The C-terminal catalytic domains of TTKs show a high degree of sequence similarity and TTKs can function as both a ser/thr protein kinase and a tyrosine protein kinase. TTKs play an important role in regulation of cell cycle progression. Studies show that human TTK is required for human cells to undergo checkpoint arrest in response to microtubule depolymerization. In addition, TTK can exert its ecntrosome-based function by modulating TACC2 in mitosis (1).

Reference
1. Dou, Z., Ding, X., Zereshki, A., Zhang, Y., Zhang, J., Wang, F., Sun, J., Huang, H. and Yao, X. (2004) TTK kinase is essential for the centrosomal localization of TACC2. FEBS Lett, 572, 51-56. PMID: 15304323

  Reviewed (0)  or Unreviewed (2) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Hea-0486	HannXRQ_Chr04g0111641	A0A251V1J1	HannXRQ_Chr04g0111641
2		iEKPD-Hea-0648	HannXRQ_Chr05g0151061	A0A251UQU6	PPK1