※ TTK family introduction

    TTK is a mammalian homolog of conserved Mps1 family members expressed in all proliferating cells and tissues. TTK was original identified by screening of a T cell expression library with anti-phosphotyrosine antibodies. The C-terminal catalytic domains of TTKs show a high degree of sequence similarity and TTKs can function as both a ser/thr protein kinase and a tyrosine protein kinase. TTKs play an important role in regulation of cell cycle progression. Studies show that human TTK is required for human cells to undergo checkpoint arrest in response to microtubule depolymerization. In addition, TTK can exert its ecntrosome-based function by modulating TACC2 in mitosis (1).

Reference
1. Dou, Z., Ding, X., Zereshki, A., Zhang, Y., Zhang, J., Wang, F., Sun, J., Huang, H. and Yao, X. (2004) TTK kinase is essential for the centrosomal localization of TACC2. FEBS Lett, 572, 51-56. PMID: 15304323

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-2216	TRIAE_CS42_4AL_TGACv1_288349_AA0945840	A0A1D5WYS1
2		iEKPD-Tra-2508	TRIAE_CS42_4BS_TGACv1_328157_AA1083650	A0A1D5XQL5
3		iEKPD-Tra-2650	TRIAE_CS42_4DS_TGACv1_361457_AA1168340	W5EPR4