※ ULK family introduction

    ULKs refer to Unc-51-like kinase which are classified into Others family. In vertebrates, at least five ULks have been found in this family and display a considerable homology to Atg1/UNC-51 in their kinase domain. Human ULK1 possesses an overall similarity of 41% to UNC-51.(1) ULK1 and ULK2 are the most closely related members of this family, sharing 78% homology of kinase domain and conserved C-terminal domain (CTD)(2). Studies show that ULK1 is critical to induce the autophagic response of cerebellar granule neurons to lowpatassium concentration in serum-free conditions.(1) ULK2 possesses the ability to compensate for the loss of ULK1 function in cell-type specific.(2) Overexpression of ULK3 is able to induce both autophagy and senescence in the human fibroblast cell line IMR90. (1)Another family member STK36 plays an important role in the sonic hedgehog pathway via regulating the activity of GLI transcription factors. Function of ULK4 remains more understood (1).

Reference
1. Alers, S., Loffler, A.S., Wesselborg, S. and Stork, B. (2012) The incredible ULKs . Cell Commun Signal, 10, 7. PMID: 22413737
2. Lee, E.J. and Tournier, C. (2011) The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy, 7, 689-695. PMID: 21460635

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-0898	SELMODRAFT_449688	D8QT32	PK
2		iEKPD-Sem-0032	SELMODRAFT_104000	D8RX58	SELMODRAFT_104000
3		iEKPD-Sem-0046	SELMODRAFT_106238	D8S1F1	SELMODRAFT_106238
4		iEKPD-Sem-0090	SELMODRAFT_111247	D8S8V4	SELMODRAFT_111247
5		iEKPD-Sem-0094	SELMODRAFT_111549	D8S8V2	SELMODRAFT_111549
6		iEKPD-Sem-0141	SELMODRAFT_118314	D8SJK6	SELMODRAFT_118314
7		iEKPD-Sem-0279	SELMODRAFT_138482	D8TFG7	SELMODRAFT_138482
8		iEKPD-Sem-0325	SELMODRAFT_15470	D8RZ86	SELMODRAFT_15470
9		iEKPD-Sem-0329	SELMODRAFT_15530	D8S2F7	SELMODRAFT_15530
10		iEKPD-Sem-0493	SELMODRAFT_234938	D8SRR3	SELMODRAFT_234938
11		iEKPD-Sem-0535	SELMODRAFT_268528	D8SF55	SELMODRAFT_268528
12		iEKPD-Sem-0656	SELMODRAFT_406291	D8R1W5	SELMODRAFT_406291
13		iEKPD-Sem-0699	SELMODRAFT_412742	D8RLB8	SELMODRAFT_412742
14		iEKPD-Sem-0715	SELMODRAFT_415764	D8RX61	SELMODRAFT_415764
15		iEKPD-Sem-0724	SELMODRAFT_417290	D8S2R1	SELMODRAFT_417290
16		iEKPD-Sem-0735	SELMODRAFT_419406	D8S8U9	SELMODRAFT_419406
17		iEKPD-Sem-0768	SELMODRAFT_425163	D8SS76	SELMODRAFT_425163
18		iEKPD-Sem-0794	SELMODRAFT_428016	D8T1F9	SELMODRAFT_428016
19		iEKPD-Sem-0836	SELMODRAFT_4377	D8RZ84	SELMODRAFT_4377
20		iEKPD-Sem-0849	SELMODRAFT_4414	D8QUQ4	SELMODRAFT_4414
21		iEKPD-Sem-0974	SELMODRAFT_67673	D8QUR1	SELMODRAFT_67673
22		iEKPD-Sem-1004	SELMODRAFT_76749	D8QT47	SELMODRAFT_76749
23		iEKPD-Sem-1162	SELMODRAFT_99641	D8RR96	SELMODRAFT_99641
24		iEKPD-Sem-1166	SELMODRAFT_99929	D8RR94	SELMODRAFT_99929