※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (10) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Amt-0077	AMTR_s00007p00211470	W1PCM4	AMTR_s00007p00211470
2		iEKPD-Amt-0301	AMTR_s00030p00123700	U5D0W9	AMTR_s00030p00123700
3		iEKPD-Amt-0338	AMTR_s00041p00109850	W1Q0A8	AMTR_s00041p00109850
4		iEKPD-Amt-0388	AMTR_s00049p00228060	W1Q0D2	AMTR_s00049p00228060
5		iEKPD-Amt-0469	AMTR_s00068p00045320	U5DFY2	AMTR_s00068p00045320
6		iEKPD-Amt-0555	AMTR_s00088p00171150	W1NRL7	AMTR_s00088p00171150
7		iEKPD-Amt-0556	AMTR_s00088p00172300	W1NVI9	AMTR_s00088p00172300
8		iEKPD-Amt-0557	AMTR_s00088p00173270	W1NWD3	AMTR_s00088p00173270
9		iEKPD-Amt-0558	AMTR_s00088p00173410	W1NY67	AMTR_s00088p00173410
10		iEKPD-Amt-0685	AMTR_s00815p00010930	U5D247	AMTR_s00815p00010930