※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (11)  or Unreviewed (0) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-0455	AT3G04910	Q9CAV6	WNK1
2		iEKPD-Art-0207	AT1G64630	Q8RXE5	WNK10
3		iEKPD-Art-0981	AT5G55560	Q6ICW6	WNK11
4		iEKPD-Art-0516	AT3G22420	Q8S8Y9	WNK2
5		iEKPD-Art-0576	AT3G48260	Q9STK6	WNK3
6		iEKPD-Art-0998	AT5G58350	Q9LVL5	WNK4
7		iEKPD-Art-0589	AT3G51630	Q9SCU5	WNK5
8		iEKPD-Art-0501	AT3G18750	Q8S8Y8	WNK6
9		iEKPD-Art-0127	AT1G49160	Q8LST2	WNK7
10		iEKPD-Art-0939	AT5G41990	Q944Q0	WNK8
11		iEKPD-Art-0904	AT5G28080	Q2V338	WNK9