※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Brd-0528	BRADI2G39347	I1HN12
2		iEKPD-Brd-0112	BRADI1G23970	I1GT70	LOC100825488
3		iEKPD-Brd-1068	BRADI4G41940	I1IU62	LOC100838132
4		iEKPD-Brd-0838	BRADI3G51457	I1ICI5	LOC100840625
5		iEKPD-Brd-1079	BRADI4G44427	I1IV11	LOC100840662
6		iEKPD-Brd-0103	BRADI1G23320	I1GSY7	LOC100841994