※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dar-0821	ENSDARG00000098550.1	A0A0G2L0F9
2		iEKPD-Dar-0571	ENSDARG00000078992.4	E7F2F9	wnk1a
3		iEKPD-Dar-2003	ENSDARG00000039392.10	A0A286Y8V5	wnk1b
4		iEKPD-Dar-0976	ENSDARG00000104989.2	A0A140LH83	wnk2
5		iEKPD-Dar-0629	ENSDARG00000088967.3	X1WGD9	wnk4b