※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Glm-0402	GLYMA_04G215200
2		iEKPD-Glm-0496	GLYMA_05G189300
3		iEKPD-Glm-1249	GLYMA_11G159900
4		iEKPD-Glm-0239	GLYMA_03G036500	I1JKY4	100170673
5		iEKPD-Glm-0684	GLYMA_07G053500	K7KZT2	100272197
6		iEKPD-Glm-2360	GLYMA_20G228000	I1NIT6	100272198
7		iEKPD-Glm-2249	GLYMA_19G242900	I1NC73	100272199
8		iEKPD-Glm-1163	GLYMA_10G248400	K7LL98	100272200
9		iEKPD-Glm-0179	GLYMA_02G235700	I1JHL5	100272203
10		iEKPD-Glm-0585	GLYMA_06G176800	I1KCA7	100272204
11		iEKPD-Glm-1693	GLYMA_14G203700	K7M872	100272207
12		iEKPD-Glm-0391	GLYMA_04G188800	I1JXC4	100301899
13		iEKPD-Glm-1125	GLYMA_10G160400	K7LJR3	100775959
14		iEKPD-Glm-2050	GLYMA_18G054100	K7MQ41	100778102
15		iEKPD-Glm-2061	GLYMA_18G081500	I1N0D5	100782039
16		iEKPD-Glm-1420	GLYMA_13G002100	I1LXJ0	100783717
17		iEKPD-Glm-1607	GLYMA_14G016400	I1M6J6	100786910
18		iEKPD-Glm-0310	GLYMA_03G245500	K7KGV1	100790554
19		iEKPD-Glm-0213	GLYMA_02G306500	I1JJR2	100798280
20		iEKPD-Glm-2324	GLYMA_20G145800	K7N3H6	100804179
21		iEKPD-Glm-1603	GLYMA_14G006600	K7M473	100807414
22		iEKPD-Glm-1840	GLYMA_16G022600	K7MES8	100809602
23		iEKPD-Glm-0211	GLYMA_02G297200	I1JJG5	100816060
24		iEKPD-Glm-0046	GLYMA_01G132000	K7K3L1	100816187
25		iEKPD-Glm-0927	GLYMA_08G325600	I1KYG5	100818126
26		iEKPD-Glm-0575	GLYMA_06G151000	I1KBH2	GLYMA_06G151000
27		iEKPD-Glm-1101	GLYMA_10G092400	K7LIA1	GLYMA_10G092400
28		iEKPD-Glm-2104	GLYMA_18G215100	K7MTV0	GLYMA_18G215100
29		iEKPD-Glm-g040	GLYMA_19G060000	K7MWU7	GLYMA_19G060000
30		iEKPD-Glm-1068	GLYMA_09G276300	C0M0Q1	WNK10
31		iEKPD-Glm-2265	GLYMA_20G066900	C0M0P9	WNK8