※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (14) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gor-0037	B456_001G064400	A0A0D2PMK3	B456_001G064400
2		iEKPD-Gor-0198	B456_002G096100	A0A0D2M8R1	B456_002G096100
3		iEKPD-Gor-0284	B456_003G069600	A0A0D2QGR4	B456_003G069600
4		iEKPD-Gor-0286	B456_003G075600	A0A0D2RIL7	B456_003G075600
5		iEKPD-Gor-0358	B456_004G150400	A0A0D2PCA5	B456_004G150400
6		iEKPD-Gor-0424	B456_005G042400	A0A0D2PMJ7	B456_005G042400
7		iEKPD-Gor-0662	B456_006G269500	A0A0D2QHI1	B456_006G269500
8		iEKPD-Gor-0731	B456_007G167300	A0A0D2SLF3	B456_007G167300
9		iEKPD-Gor-0799	B456_007G285300	A0A0D2PG64	B456_007G285300
10		iEKPD-Gor-0930	B456_008G257300	A0A0D2RMC3	B456_008G257300
11		iEKPD-Gor-1373	B456_011G128900	A0A0D2T7D3	B456_011G128900
12		iEKPD-Gor-1499	B456_012G033500	A0A0D2RWV1	B456_012G033500
13		iEKPD-Gor-1610	B456_013G156000	A0A0D2VEA2	B456_013G156000
14		iEKPD-Gor-1647	B456_013G2721001	A0A0D2VKV9	B456_013G2721001