※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Lua-0050	TanjilG_05494	A0A1J7HVD3	TanjilG_05494
2		iEKPD-Lua-0208	TanjilG_12131	A0A1J7GW90	TanjilG_12131
3		iEKPD-Lua-0394	TanjilG_20558	A0A1J7FNC5	TanjilG_20558
4		iEKPD-Lua-0396	TanjilG_20866	A0A1J7HP31	TanjilG_20866
5		iEKPD-Lua-0403	TanjilG_20995	A0A1J7H9D3	TanjilG_20995
6		iEKPD-Lua-0461	TanjilG_24060	A0A1J7HJR5	TanjilG_24060
7		iEKPD-Lua-0541	TanjilG_29280	A0A1J7ILA4	TanjilG_29280