※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (17) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-0102	MANES_02G004300	A0A2C9W9X5	MANES_02G004300
2		iEKPD-Mae-0276	MANES_03G137500	A0A2C9W789	MANES_03G137500
3		iEKPD-Mae-0289	MANES_03G179200	A0A2C9W8H4	MANES_03G179200
4		iEKPD-Mae-0403	MANES_05G020200	A0A2C9VUQ3	MANES_05G020200
5		iEKPD-Mae-0527	MANES_06G111100	A0A2C9VS78	MANES_06G111100
6		iEKPD-Mae-0691	MANES_08G128000	A0A2C9VFV6	MANES_08G128000
7		iEKPD-Mae-0713	MANES_08G173900	A0A2C9VH50	MANES_08G173900
8		iEKPD-Mae-0759	MANES_09G116600	A0A2C9VA61	MANES_09G116600
9		iEKPD-Mae-0774	MANES_09G156300	A0A2C9VBC8	MANES_09G156300
10		iEKPD-Mae-1024	MANES_12G062300	A0A2C9UU93	MANES_12G062300
11		iEKPD-Mae-1067	MANES_12G151900	A0A2C9UXY8	MANES_12G151900
12		iEKPD-Mae-1090	MANES_13G063300	A0A2C9UPI7	MANES_13G063300
13		iEKPD-Mae-1094	MANES_13G071400	A0A2C9UPS7	MANES_13G071400
14		iEKPD-Mae-1203	MANES_15G028800	A0A2C9UDH0	MANES_15G028800
15		iEKPD-Mae-1219	MANES_15G063800	A0A2C9UEK2	MANES_15G063800
16		iEKPD-Mae-1476	MANES_18G139300	A0A2C9U4X4	MANES_18G139300
17		iEKPD-Mae-1486	MANES_S026500	A0A199UBU2	MANES_S026500