※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Met-0208	MTR_1g081330	G7I7D3	11410726
2		iEKPD-Met-0575	MTR_3g076650	G7J485	11419063
3		iEKPD-Met-0542	MTR_3g056010	G7J1J0	11420458
4		iEKPD-Met-0622	MTR_3g095680	G7JAY9	11423050
5		iEKPD-Met-0023	MTR_0283s0050	G7KEQ5	11424782
6		iEKPD-Met-1368	MTR_7g114680	G7L0U9	11425669
7		iEKPD-Met-1282	MTR_7g072640	G7KX47	11426655
8		iEKPD-Met-0584	MTR_3g080960	G7J815	11429051
9		iEKPD-Met-0634	MTR_3g099940	G7J4J3	11432281
10		iEKPD-Met-1073	MTR_5g094390	G7K4D4	11433675
11		iEKPD-Met-1014	MTR_5g075220	G7K0S2	11435320
12		iEKPD-Met-0548	MTR_3g062420	G7IV38	11438061
13		iEKPD-Met-1548	MTR_8g093090	G7LD56	11440965
14		iEKPD-Met-0252	MTR_1g103850	A0A072VPH6	25485218
15		iEKPD-Met-g018	MTR_3g056013	A0A072UY09	25489060
16		iEKPD-Met-0543	MTR_3g056025	A0A072UVY5	25489062
17		iEKPD-Met-0703	MTR_4g028830	A0A072UIC0	25491702
18		iEKPD-Met-1098	MTR_6g016260	A0A072U7S5	25495476
19		iEKPD-Met-1220	MTR_7g029020	A0A072TX48	25497806
20		iEKPD-Met-1437	MTR_8g027265	A0A072TMG1	25500648