※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nia-0686	A4A49_64712	A0A1J6JSJ4	WNK11_1
2		iEKPD-Nia-0339	A4A49_24746	A0A1J6J0D8	WNK11_3
3		iEKPD-Nia-0646	A4A49_56472	A0A1J6IB68	WNK2_1
4		iEKPD-Nia-0420	A4A49_29191	A0A1J6IYZ5	WNK4_1
5		iEKPD-Nia-0424	A4A49_29572	A0A1J6I351	WNK4_2
6		iEKPD-Nia-0478	A4A49_33360	A0A1J6IU22	WNK4_3
7		iEKPD-Nia-0497	A4A49_34476	A0A1J6KQ97	WNK5
8		iEKPD-Nia-0499	A4A49_34559	A0A1J6IMX6	WNK8_3