Oreochromis niloticus      Other/WNK


※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Orn-0194
ENSONIG00000007191.1
I3JJM3
2
iEKPD-Orn-0210
ENSONIG00000007921.1
I3JM89
3
iEKPD-Orn-0354
ENSONIG00000011712.1
I3K0V3
4
iEKPD-Orn-1566
ENSONIG00000014819.1
I3KC12
5
iEKPD-Orn-0505
ENSONIG00000017202.1
I3KKQ5
WNK2 (1 of many)
6
iEKPD-Orn-0368
ENSONIG00000012008.1
I3K1X0
WNK3