※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Phv-0249	PHAVU_002G270000g	V7CSB0	PHAVU_002G270000g
2		iEKPD-Phv-0575	PHAVU_006G000200g	V7BLN9	PHAVU_006G000200g
3		iEKPD-Phv-0591	PHAVU_006G053100g	V7BKR5	PHAVU_006G053100g
4		iEKPD-Phv-0601	PHAVU_006G077100g	V7BLN3	PHAVU_006G077100g
5		iEKPD-Phv-0614	PHAVU_006G099700g	V7BMH0	PHAVU_006G099700g
6		iEKPD-Phv-0722	PHAVU_007G057000g	V7BEB6	PHAVU_007G057000g
7		iEKPD-Phv-0770	PHAVU_007G185900g	V7BH07	PHAVU_007G185900g
8		iEKPD-Phv-0879	PHAVU_008G084000g	V7B6I4	PHAVU_008G084000g
9		iEKPD-Phv-0967	PHAVU_008G248200g	V7BB06	PHAVU_008G248200g
10		iEKPD-Phv-0980	PHAVU_008G275100g	V7BD13	PHAVU_008G275100g
11		iEKPD-Phv-0983	PHAVU_008G286300g	V7B9I9	PHAVU_008G286300g
12		iEKPD-Phv-1043	PHAVU_009G148000g	V7AWP0	PHAVU_009G148000g
13		iEKPD-Phv-1052	PHAVU_009G173100g	V7AXH6	PHAVU_009G173100g
14		iEKPD-Phv-1121	PHAVU_010G067900g	V7AQ15	PHAVU_010G067900g
15		iEKPD-Phv-1141	PHAVU_010G115800g	V7ANN1	PHAVU_010G115800g