※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pot-0046	POPTR_0001s11210	B9GK92	POPTR_0001s11210g
2		iEKPD-Pot-0321	POPTR_0003s14520	B9GXV6	POPTR_0003s14520g
3		iEKPD-Pot-0531	POPTR_0005s05140	B9H666	POPTR_0005s05140g
4		iEKPD-Pot-0537	POPTR_0005s05860	U5GAT6	POPTR_0005s05860g
5		iEKPD-Pot-0831	POPTR_0008s03700	B9HLI9	POPTR_0008s03700g
6		iEKPD-Pot-0866	POPTR_0008s15170	B9HJX3	POPTR_0008s15170g
7		iEKPD-Pot-0995	POPTR_0010s09830	U5FYA1	POPTR_0010s09830g
8		iEKPD-Pot-1039	POPTR_0010s23190	B9HUH7	POPTR_0010s23190g
9		iEKPD-Pot-1229	POPTR_0012s08860	B9I3F6	POPTR_0012s08860g
10		iEKPD-Pot-1305	POPTR_0013s15110	B9I6V9	POPTR_0013s15110g
11		iEKPD-Pot-1340	POPTR_0014s09700	B9I908	POPTR_0014s09700g
12		iEKPD-Pot-1360	POPTR_0014s16200	B9IAQ4	POPTR_0014s16200g
13		iEKPD-Pot-1406	POPTR_0015s09610	B9IEZ5	POPTR_0015s09610g
14		iEKPD-Pot-1485	POPTR_0016s14210	B9IGR4	POPTR_0016s14210g
15		iEKPD-Pot-1739	POPTR_0019s14910	B9INN1	POPTR_0019s14910g
16		iEKPD-Pot-1759	POPTR_0030s00490	U7E2W0	POPTR_0030s00490g