※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-0113	SELMODRAFT_11342	D8SU99	SELMODRAFT_11342
2		iEKPD-Sem-0189	SELMODRAFT_126389	D8SW37	SELMODRAFT_126389
3		iEKPD-Sem-0190	SELMODRAFT_126444	D8SWL2	SELMODRAFT_126444
4		iEKPD-Sem-0217	SELMODRAFT_130367	D8T299	SELMODRAFT_130367
5		iEKPD-Sem-0248	SELMODRAFT_134163	D8T849	SELMODRAFT_134163
6		iEKPD-Sem-0250	SELMODRAFT_134331	D8T8A1	SELMODRAFT_134331
7		iEKPD-Sem-0266	SELMODRAFT_136322	D8TBL0	SELMODRAFT_136322