※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-0854	Si026086m.g	K3ZHN4	LOC101757253
2		iEKPD-Sei-0360	Si009574m.g	K3Y5T5	LOC101768340
3		iEKPD-Sei-1126	Si032842m.g	K4A1U7	LOC101769023
4		iEKPD-Sei-0897	Si027310m.g	K3ZL54	LOC101775905
5		iEKPD-Sei-1043	Si029371m.g	K3ZRZ1	LOC101780337
6		iEKPD-Sei-0708	Si021438m.g	K3Z4H0	LOC101780895
7		iEKPD-Sei-0567	Si016704m.g	K3YR10	LOC101783004
8		iEKPD-Sei-0387	Si011766m.g	K3YC22	LOC101783715
9		iEKPD-Sei-1025	Si029157m.g	K3ZRC7	LOC101783980