※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sol-0061	Solyc01g096170.2	K4B006
2		iEKPD-Sol-0355	Solyc03g112140.2	K4BK68
3		iEKPD-Sol-0551	Solyc05g041420.2	K4C0C3
4		iEKPD-Sol-0939	Solyc10g009350.2	K4CYB1
5		iEKPD-Sol-1037	Solyc11g039590.1	K4D7T8
6		iEKPD-Sol-0069	Solyc01g097840.2	K4B0H1	101243743
7		iEKPD-Sol-0658	Solyc06g082470.2	K4CAA6	101246543
8		iEKPD-Sol-0239	Solyc02g087590.1	K4BBR6	101246689
9		iEKPD-Sol-0938	Solyc10g009060.1	K4CY82	101247262
10		iEKPD-Sol-0905	Solyc09g076000.2	K4CVH7	101253529
11		iEKPD-Sol-0644	Solyc06g071800.2	K4C8Q2	101255500
12		iEKPD-Sol-0876	Solyc09g018170.2	K4CS84	101255722
13		iEKPD-Sol-0765	Solyc07g065250.2	K4CHK4	101256991
14		iEKPD-Sol-0703	Solyc07g047990.1	K4CF03	101261432
15		iEKPD-Sol-0836	Solyc08g082980.2	K4CPU4	101267728