※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sot-0003	PGSC0003DMG400000122	M0ZGK9
2		iEKPD-Sot-0121	PGSC0003DMG400004415	M0ZZB1
3		iEKPD-Sot-0531	PGSC0003DMG400018191	M1BJR3
4		iEKPD-Sot-1156	PGSC0003DMG402026985	M1CKE4
5		iEKPD-Sot-g013	PGSC0003DMG400018885	M1BMN4
6		iEKPD-Sot-0917	PGSC0003DMG400030087	M1CYA1	102581254
7		iEKPD-Sot-1050	PGSC0003DMG400047254	M1E165	102583213
8		iEKPD-Sot-0656	PGSC0003DMG400022188	M1C0F5	102592322
9		iEKPD-Sot-0926	PGSC0003DMG400030274	M1CYZ1	102592861
10		iEKPD-Sot-1132	PGSC0003DMG402012244	M1AWH6	102594076
11		iEKPD-Sot-0170	PGSC0003DMG400006134	M1A6F1	102597607
12		iEKPD-Sot-0665	PGSC0003DMG400022507	M1C1X6	102599481
13		iEKPD-Sot-0935	PGSC0003DMG400030463	M1CZS2	102602509
14		iEKPD-Sot-0997	PGSC0003DMG400036177	M1DC43	107060312
15		iEKPD-Sot-0676	PGSC0003DMG400022825	M1C390	107063341