※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sob-0218	SORBI_3002G056500	A0A1B6Q9E1	SORBI_3002G056500
2		iEKPD-Sob-0338	SORBI_3002G348000	C5XCB4	SORBI_3002G348000
3		iEKPD-Sob-0342	SORBI_3002G355100	C5XCH5	SORBI_3002G355100
4		iEKPD-Sob-0663	SORBI_3004G284800	C5Y1A5	SORBI_3004G284800
5		iEKPD-Sob-0702	SORBI_3005G012200	C5Y3F8	SORBI_3005G012200
6		iEKPD-Sob-0714	SORBI_3005G045800	C5Y557	SORBI_3005G045800
7		iEKPD-Sob-0993	SORBI_3008G046300	C5YS92	SORBI_3008G046300
8		iEKPD-Sob-1061	SORBI_3009G008200	C5YYE0	SORBI_3009G008200