※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Asg-0107	AGOS_AAL162C	Q75F93	AGOS_AAL162C
2		iEKPD-Asg-0116	AGOS_ACR239C	Q75BN2	AGOS_ACR239C
3		iEKPD-Asg-0120	AGOS_ADL377W	Q75BE1	AGOS_ADL377W
4		iEKPD-Asg-0123	AGOS_AEL010W	Q757M1	AGOS_AEL010W
5		iEKPD-Asg-0134	AGOS_AGL223C	Q751C9	AGOS_AGL223C
6		iEKPD-Asg-0137	AGOS_AGR363W	Q74Z43	AGOS_AGR363W