※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Asf-0150	AFLA_002820	B8NPX9	AFLA_002820
2		iEKPD-Asf-0165	AFLA_080820	B8MYE4	AFLA_080820
3		iEKPD-Asf-0166	AFLA_083620	B8MZ73	AFLA_083620
4		iEKPD-Asf-0168	AFLA_088320	B8MWE2	AFLA_088320
5		iEKPD-Asf-0172	AFLA_094490	B8NLZ3	AFLA_094490
6		iEKPD-Asf-0174	AFLA_107370	B8N8E3	AFLA_107370
7		iEKPD-Asf-0180	AFLA_128130	B8NP30	AFLA_128130