※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Asa-0130	CADANIAG00001742	Q5BEW6	ANIA_00914
2		iEKPD-Asa-0127	CADANIAG00001253	C8VRX1	ANIA_01358
3		iEKPD-Asa-0155	CADANIAG00008084	Q5BDB3	ANIA_01467
4		iEKPD-Asa-0157	CADANIAG00009192	Q5BAF8	ANIA_02472
5		iEKPD-Asa-0154	CADANIAG00007693	Q5AXT8	ANIA_06892
6		iEKPD-Asa-0134	CADANIAG00002405	C8VU36	ANIA_10064
7		iEKPD-Asa-0141	CADANIAG00004783	G5EB41	cyaA