※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Aso-0158	AO090001000512	Q2UN43	AO090001000512
2		iEKPD-Aso-0164	AO090005000830	Q2URH1	AO090005000830
3		iEKPD-Aso-0165	AO090005001120	Q2UQS6	AO090005001120
4		iEKPD-Aso-0168	AO090005001595	Q2UPL5	AO090005001595
5		iEKPD-Aso-0178	AO090023000321	Q2UHT3	AO090023000321
6		iEKPD-Aso-0183	AO090102000158	Q2UB08	AO090102000158
7		iEKPD-Aso-0187	AO090120000479	Q2U5W9	AO090120000479